What Is the Maximum Dose of Depakote Per Day

Typical maximum doses

• Adults: The Depakote maximum daily dosage is usually 3000 mg per day
• Children: Dosing is typically based on weight, with a maximum of 60 mg/kg/day
• Elderly: Lower maximum doses may be recommended due to decreased clearance

Condition-specific maximum doses

• Epilepsy:

  • Maximum doses up to 3000 mg/day are common
  • Some trials have used doses up to 2961 mg/day

• Bipolar disorder:

  • Doses typically range from 500-2000 mg/day
  • A study found efficacy at 1000 mg/day with 70% response rate

• Migraine prevention:

  • Usually lower doses are effective, typically not exceeding 1500 mg/day

Factors affecting maximum dose

• Extended-release vs. delayed-release: Extended-release formulations may require 12% higher doses to achieve equivalent plasma levels
• Individual patient factors: Age, weight, liver function, and concomitant medications can affect the highest safe dose of divalproex sodium

Safety considerations

• Adverse events: Higher doses increase the risk of side effects
• Therapeutic drug monitoring: Plasma levels should be monitored, especially at higher doses
• Gradual titration: Doses should be increased slowly to minimize side effects

Alternative medications

• Perampanel (PER): Shown to be effective in replacing Depakote, with improved seizure control in some cases
• Levetiracetam (LEV) and Lamotrigine (LTG): Non-inferior alternatives for certain conditions

FAQ

What is the maximum dose of Depakote per day for adults?

The maximum dose of Depakote per day for most adults is typically 3000 mg. However, in some clinical trials, doses up to 4000 mg daily have been used for certain conditions.

How is the Depakote maximum daily dosage determined for children?

For children, the Depakote maximum daily dosage is usually based on weight, with a maximum of 60 mg/kg/day.

What is the highest safe dose of divalproex sodium for epilepsy treatment?

The highest safe dose of divalproex sodium for epilepsy treatment is generally up to 3000 mg/day. Some clinical trials have used doses up to 2961 mg/day.

Does the Depakote maximum daily dosage differ for extended-release formulations?

Yes, extended-release formulations of Depakote may require approximately 12% higher doses to achieve equivalent plasma levels compared to delayed-release formulations.

What factors can affect the highest safe dose of divalproex sodium?

The highest safe dose of divalproex sodium can be affected by factors such as age, weight, liver function, and concomitant medications. Additionally, individual patient response and tolerance to the medication may influence the maximum dose.